Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling
نویسندگان
چکیده
منابع مشابه
Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling.
RATIONALE It is now believed that both chronic airway inflammation and remodeling contribute significantly to airway dysfunction and clinical symptoms in allergic asthma. Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis o...
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All three isoforms of transforming growth factors beta (TGF-betal, TGF-beta2, and TGF-beta3) are secreted as latent complexes and activated extracellularly, leading to the release of the mature cytokines from their noncovalently associated proregions, also known as latency-associated peptides (LAPs). The LAP region of TGF-beta1 was expressed in a baculovirus expression system and purified to ho...
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OBJECTIVES The purpose of this study was to evaluate the oral health-related quality of life of patients treated with implant-supported mandibular overdentures and to compare the attachment systems used. MATERIAL AND METHODS The presence of myofibroblasts as well as transforming growth factor-beta1 was examined in twenty cases of fibrous epulis and 22 ossifying fibrous epulis, using immunohis...
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BACKGROUND In a case-control study of 100 preeclamptics and 100 controls, we assessed plasma transforming growth factor-beta1 (TGF-beta1) concentrations in relation to preeclampsia risk among Peruvian women with and without systemic inflammation. METHODS Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS The OR of preeclampsia increased ac...
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ژورنال
عنوان ژورنال: Allergy
سال: 2012
ISSN: 0105-4538
DOI: 10.1111/j.1398-9995.2012.02880.x